Statistical significance of gene modules.

The table shows results of a global test [49], assessing the differential gene set expression of each gene module between WT and down-expression/KO of CD33. P-values of the test within simulated scenario, as well as, p-values from cell line KO are reported and corrected for multiple testing using the Benjamini-Hochberg method. The agreement of both tests is described in the last column, meaning if both tests are either significant or non-significant (+) or if they don’t show same direction of significance (-). For GRIN1 no p-value could be computed, as that gene is not present in the cell line data.