Crystal structure of human DNPH1 bound to inhibitor 2c
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Crystal structure of human DNPH1 bound to inhibitor 2c Descriptor: 5-hydroxymethyl-dUMP N-hydrolase, [(3R,4R)-4-hydroxy-1-{[5-(hydroxymethyl)pyridin-3-yl]methyl}pyrrolidin-3-yl]methyl dihydrogen phosphate Authors: Wagner, A.G, Schramm, V.L, Almo, S.C, Ghosh, A. Deposit date: 2024-08-21 Release date: 2025-02-05 Last modified: 2025-02-26 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Transition State Analogs of Human DNPH1 Reveal Two Electrophile Migration Mechanisms. J.Med.Chem., 68, 2025
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2024-08-21
