Cis eQTL analysis of SLC2A2 in human liver tissue

A three-stage genome wide association study (GWAS) reports the finding of the C-allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (p=6.6x10-14) greater metformin induced HbA1c reduction in 10,577 participants of European ancestry (doi:10.1038/ng.3632). The SNP, rs8192675 is the top cis-eQTL for SLC2A2 in 1,226 human liver samples, suggesting a key role for hepatic GLUT2 in regulation of metformin action. Here, we deposit the SLC2A2 transcript levels (see Supplemental Table A) in 583 human liver samples and their genotypes within the SLC2A2 region (see Supplemental Table B). The data here are referred to as data set 4 in the published GWAS (doi:10.1038/ng.3632).