CANONICAL SNPs.

CanSNPs and profiles for the lineages/groups: This table lists each of the 12 lineages and groups and indicates the canonical SNPs that help to define each of the sub-lineages and sub-groups (canSNPs that define a particular sub-lineage or sub-group are indicated in yellow). Each lineage is named after the whole genome sequence that is positioned as an end point in a branch created by a comparison of that particular genome sequence to 6 other genomes (stars in Figures 1 and 3). As endpoints all but one of the lineages are defined by a single canSNP (see profiles in yellow for B.Br.Kruger , B.Br.CNEVA, A.Br.Vollum, A.Br.Ames and A.Br.WNA. Although Aust94 is an endpoint the canSNPs that define this lineage were developed before the draft sequence and as a result two canSNPs A.Br.002 and A.Br.003 define the branch point where this isolate is located. Similarly, the groups are positions that define branch points [5], [35] along the different lineages (Circles in Fig. 1 and 3). They carry the group name designations corresponding to the canSNPs that flank these positions and are indicated in blue in this table (e.g. A.Br.001/002). Note that the sub-group need at least two canSNPs (one SNP on either side of the node) to assign a correct sub-group. Sub-group A.Br.005/006 requires three canSNPs to assign an exact genotype because a canSNP for A.Br.005 has not yet been tested. The whole genome sequences for Bacillus anthracis strains A0155, Ames Ancestor, CNEVA-9066, Kruger B, Vollum, Western North America (WNA) and Australia 94 can be found in the NCBI microbial genome website at http://www.ncbi.nlm.nih.gov