Structure of N289A mutant of AmpC in complex with SM3, a phenylglyclboronic acid bearing the cephalothin R1 side chain

Structure of N289A mutant of AmpC in complex with SM3, a phenylglyclboronic acid bearing the cephalothin R1 side chain Descriptor: (1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION, ... Authors: Roth, T.A, Minasov, G, Focia, P.J, Shoichet, B.K. Deposit date: 2003-05-29 Release date: 2004-02-24 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Thermodynamic cycle analysis and inhibitor design against beta-lactamase. Biochemistry, 42, 2003

携带头孢噻吩R1侧链的苯基甘氨酸硼酸类化合物SM3与AmpC的N289A突变体的复合物结构。组分标识：(1R)-1-(2-噻吩乙酰氨基)-1-苯甲基硼酸、β-内酰胺酶(Beta-lactamase)、磷酸根离子…… 作者：Roth, T.A、Minasov, G、Focia, P.J、Shoichet, B.K. 提交日期：2003-05-29；发布日期：2004-02-24；最后修订日期：2024-10-30。实验方法：X射线衍射(X-RAY DIFFRACTION)（分辨率1.39埃）。引用文献：《针对β-内酰胺酶的热力学循环分析与抑制剂设计》，《生物化学》，第42卷，2003年。