five

Low_DEN_treatment

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/ERP164042
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This work complements our whole genome crispr screen which has identified several genes that seem to have a positive effect on cellular fitness in vitro. We wish to investigate if these genes are still under positive selection in vivo. We have exposed bl6 mice to a low dose of diethyl-nitrosamine and then aged them. 2mm2 pieces of oesophageal epithelium will be sequenced at high depth using a targeted bait panel of predicted driver genes.
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2026-02-20
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