Mecp2 fine-tunes quiescence exit by targeting nuclear receptors [RNA-Seq]

To identify the MeCP2 targets gene during the very early stage of liver regeneration，ChIP-seq analyses in control and Mecp2-cKO mice livers before and 6 h after PHx were performed. We found 3048 Mecp2-dependent genes that were differentially expressed in a Mecp2-dependent manner. Ten to 12-week-old male control and MeCP2-KO mouse liver samples were obtained at 0 and 6 hours after 2/3 PH. mRNAs differentially expressed were identified by comparing expression levels during liver regeneration in mice after 2/3 partial hepatectomy (PH) at various time points.