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FBL promotes cancer cell resistance to DNA damage by transcriptionally regulating BRCA1 via YBX1

NIAID Data Ecosystem2026-05-01 收录

癌细胞耐药性

DNA损伤修复

数据链接：

https://www.omicsdi.org/dataset/biostudies-other/S-BSST1093 数据链接链接失效反馈

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FBL promotes cancer cell resistance to DNA damage by transcriptionally regulating BRCA1 via YBX1 Figure 6

应用场景：

创建时间：

2023-05-24

DNA损伤修复

染色质调控

Cohesin and the PBAF chromatin remodelling complex are required to repress transcription at sites of DNA double strand breaks. To investigate this and rule out known sister-chromatid dependent functio

NIAID Data Ecosystem60

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure)

结构生物学

DNA损伤修复

Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure)

NIAID Data Ecosystem00

Cytotoxicity of Ruthenium–Arene Complexes Containing β‑Ketoamine Ligands

金属配合物抗癌

癌细胞耐药性

New ruthenium(II) arene derivatives (arene = p-cymene, benzene, hexamethylbenzene) containing β-ketoamine ligands L′ (HL′ in general; in detail, HLph,ph = (4Z)-3-methyl-4-((phenylamino)(phenyl)meth

NIAID Data Ecosystem50

Data and code for analyzing DSB mobility

DNA损伤修复

肌动蛋白动力学

Double-strand breaks (DSBs) are critical lesions in genomic DNA, and their accurate repair is essential for maintaining genome stability. The nuclear actin cytoskeleton has been implicated in homology

DataCite Commons2025-10-22 更新40

FBL promotes cancer cell resistance to DNA damage by transcriptionally regulating BRCA1 via YBX1

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