Chronic GVHD has similar or worse impact on skin-specific quality of life than autoimmune connective tissue diseases: a cross-sectional study

Supplemental figures to support JAAD publication: Chronic GVHD has similar or worse impact on skin-specific quality of life than autoimmune connective tissue diseases: a cross-sectional study Supplemental figure 1. Sensitivity analysis of skin-specific quality of life in chronic graft-versus-host disease subtypes (epidermal, sclerotic, and combination) compared to dermatomyositis and cutaneous lupus erythematosus. Multivariate linear regression models adjusted for age, sex, and race demonstrate Skindex-29 scores were on average worse in epidermal and combination cGVHD compared to DM while there was no statistical difference for sclerotic cGVHD. This difference was clinically significant in total and subscale scores aside from the symptom subscale for combination disease. Skindex-29 scores were not statistically different in epidermal or combination cGVHD compared to CLE while total, symptom, and emotion scores were on average worse with clinically significant differences in CLE compared to sclerotic cGVHD. Point estimates have similar trends to primary analysis with wider confidence intervals due to smaller sample size per group. Supplemental figure 2. Sensitivity analysis of skin-specific quality of life in chronic graft-versus-host disease compared to dermatomyositis and cutaneous lupus erythematosus adjusting for clinical disease severity. Multivariate linear regression models comparing ssQoL in DM (n=332), CLE (n=85), and a subgroup of cGVHD in which clinical disease severity grading was available (n=35). When adjusting for disease severity, CLE had worse ssQOL in total score and emotion subscales in addition to the symptom subscale compared to cGVHD, which were clinically significant. Point estimates overall have similar trends to primary analysis with wider confidence intervals due to smaller sample size per group. Disease severity was measured by NIH Skin Score (0-3) with mild = 1, moderate/severe ≥2, Cutaneous Lupus Erythematosus Disease Area and Severity Index (0-100) with mild ≤14, moderate/severe > 14, and Cutaneous Lupus Erythematosus Disease Area and Severity Index (0-70) with mild ≤ 9, moderate/severe > 9.用于支持《JAAD》发表的补充图表：慢性移植物抗宿主病对皮肤特异性生活质量的影响与自身免疫性结缔组织病相似甚至更差——一项横断面研究 补充图1：慢性移植物抗宿主病（chronic graft-versus-host disease, cGVHD）亚型（表皮型、硬化型及混合型）与皮肌炎（dermatomyositis, DM）及皮肤红斑狼疮（cutaneous lupus erythematosus, CLE）相比的皮肤特异性生活质量敏感性分析。针对年龄、性别和种族进行校正的多变量线性回归模型显示，相较于皮肌炎组，表皮型和混合型慢性移植物抗宿主病患者的Skindex-29评分平均更差，而硬化型慢性移植物抗宿主病则无统计学差异。该差异在总分及除症状维度外的各子维度评分中具有临床意义，混合型患者的症状维度评分则无此差异。相较于皮肤红斑狼疮组，表皮型和混合型慢性移植物抗宿主病患者的Skindex-29评分无统计学差异；而皮肤红斑狼疮组的总分、症状维度及情绪维度评分平均更差，且与硬化型慢性移植物抗宿主病相比存在具有临床意义的差异。由于各组样本量较小，点估计值与主要分析趋势一致，但置信区间更宽。 补充图2：慢性移植物抗宿主病与皮肌炎及皮肤红斑狼疮相比的皮肤特异性生活质量敏感性分析（校正临床疾病严重程度）。本研究纳入皮肌炎组（n=332）、皮肤红斑狼疮组（n=85），以及存在临床疾病严重程度分级数据的慢性移植物抗宿主病亚组（n=35），采用多变量线性回归模型比较各组皮肤特异性生活质量评分。在校正疾病严重程度后，相较于慢性移植物抗宿主病组，皮肤红斑狼疮组的总分、情绪维度及症状维度评分均更差，且差异具有临床意义。由于各组样本量较小，整体点估计值与主要分析趋势一致，但置信区间更宽。疾病严重程度评估采用如下标准：美国国立卫生研究院皮肤评分（NIH Skin Score，0~3分，轻度为1分，中度/重度≥2分）、皮肤红斑狼疮疾病面积和严重程度指数（Cutaneous Lupus Erythematosus Disease Area and Severity Index，0~100分，轻度≤14分，中度/重度＞14分），以及另一版本皮肤红斑狼疮疾病面积和严重程度指数（0~70分，轻度≤9分，中度/重度＞9分）。