A study of SMC TGFb signaling in hypercholesterolemic patients with aortic aneurysms Chen et al. RElated To fig 1.

Smooth muscle cell (SMC) TGFb signaling and expression of relevant genes in the media of normal human aortas and non-Marfan atherosclerotic ascending aorta aneurysms by bulk RNAseq and immunocytochemistry. Related To Fig 1. SMC aneurysms samples show a reduction in TGFb signaling and increased expression of inflammation-related genes compared to normal aortas SMCs.本数据集通过批量RNA测序（bulk RNAseq）与免疫细胞化学（immunocytochemistry）技术，解析了正常人类主动脉中膜以及非马凡综合征性动脉粥样硬化性升主动脉瘤组织内平滑肌细胞（Smooth muscle cell, SMC）的转化生长因子β（TGFβ）信号通路与相关基因的表达情况。本数据集与图1相关。相较于正常主动脉平滑肌细胞，动脉瘤来源的平滑肌细胞样本呈现出转化生长因子β信号通路活性降低、炎症相关基因表达上调的特征。