Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that mostly strikes the elderly. However, the exact molecular and cellular pathogenesis of AD, especially the dynamic changes of ne

NIAID Data Ecosystem60

Single-cell Sequencing of Microglia following Repopulation Reveals Distinct Clusters and Transcriptomic Signatures in the 3xTg Alzheimer's Disease Model

小胶质细胞再增殖

阿尔茨海默病转录组

In this study, we aimed to deplete the aging microglia and investigate the impact of the newly-born microglia in Alzheimer's pathology using the 3xTg mouse model. Specifically, >24 mo male 3xTg mice w

NIAID Data Ecosystem60

Olfactory_transcriptomics_in_a_mouse_model_of_Alzheimer_s_disease. Olfactory_transcriptomics_in_a_mouse_model_of_Alzheimer_s_disease

阿尔茨海默病转录组

嗅觉上皮基因表达

High-throughput sequencing of RNA from olfactory epithelium of mice modeling Alzheimer's disease with olfactory deficits. We sequenced cDNA libararies from the main olfactory epithelium (MOE) of nine

NIAID Data Ecosystem60

Diversity of astrocytes across the mouse CNS [scRNA-seq]

胶质细胞异质性

阿尔茨海默病转录组

We assessed astrocyte diversity in the cortex, hippocampus, and striatum using sing cell RNA-seq (scRNA-seq). We also assessed cortical astrocytes in wild type control and transgenic APP/PS1dE9 mice u

NIAID Data Ecosystem60

Transcriptome of cyanidin-3-O-galactoside treatment in SAMP8 mice

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