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Decorated BODIPY Fluorophores and Thiol-Reactive Fluorescence Probes by an Aldol Addition

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NIAID Data Ecosystem2026-03-10 收录
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A novel entry to meso-decorated BODIPY motifs on the basis of an unusual aldol-type addition with diethyl ketomalonate is reported. The evolving β-hydroxyl group can be optionally eliminated, which suppresses the fluorescence of the BODIPY core by attachment of a π-electronically coupled methylidene malonate unit. This unit serves as a versatile, highly electrophilic acceptor platform for various nucleophilic additions. Corresponding products benefit from a fully restored fluorescence.

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2017-04-07
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