The role of core circadian component BMAL1 or CLOCK in human bone marrow mesenchymal stem cells osteogenic capacity

To elucidate how the core circadian component BMAL1 and clock regulate the osteogenic capacity of human bone marrow MSCs, RNA-seq was performed to study the impact of diminishing core component BMAL1 or CLOCK in MSCs by lentiviruses. Examination of the mRNA profiles in human bone marrow MSCs with diminishing BMAL1 or CLOCK during osteogenic differentiation