Synthesis of Cyclopentadiene-Fused Chromanones via One-Pot Multicomponent Reactions
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https://figshare.com/articles/dataset/Synthesis_of_Cyclopentadiene_Fused_Chromanones_via_One_Pot_Multicomponent_Reactions/2433856
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资源简介：
We have developed one-pot method for the synthesis of
functionalized
novel cyclopentadiene-fused chromanone scaffolds. A variety of 4-oxo-2,4-dihydrocyclopenta[c]chromene-1,2-dicarboxylates were obtained in moderate
to good yields via condensation of 2-hydroxybenzaldehydes and ethyl
acetoacetate with 1:1 acetylenecarboxylate–isocyanides in toluene.
These reactions presumably proceed via reaction of the in situ generated
3-acetyl-2H-chromen-2-ones with acetylenecarboxylate–isocyanide
zwitterionic intermediates through Michael addition/intramolecular
cyclization and double [1,5] acyl shift rearrangement cascade.
创建时间：
2016-02-19
