Associations of genetic loci with MI in primary and replication analyses.

αOnly SNPs associated with MI with a nominal P<0.01 in STR are presented. Data are hazard ratios with 95% confidence intervals and P-values from Cox proportional hazards regression models using age as time scale and study entry at age 18, adjusting for sex. The effect allele was defined as the minor allele in our study.
βProxies rs2236513, rs4759275, and rs8066560 were used instead of lead SNPs rs3183702, rs11172106 and rs9899634, respectively in ULSAM (r2 = 1, 0.84 and 1) in all the results from the replication study.
γCELSR2 and SORT1 reside in a cluster consisting of CELSR2/PSRC1/SORT1; APOA4 resides in a cluster of apolipoproteins APOA5/APOA4/APOC3/APOA1.
δrs5090 was not successfully genotyped in ULSAM.
εAlleles are presented as effect/other alleles.
Abbreviations: SNP, single nucleotide polymorphism; HR, hazard ratio; CI, confidence interval.