Additional file 2 of Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes

Additional file 2: Table S1A. Description of the open-chromatin sites of primary tumours and related normal tissues used in the analysis. Table S1B. Localised mutation frequencies in three classes of genomic sites across total mutations and subsets of mutations (total mutations, SBS signatures, ref./alt pairs). Table S1C. Localised mutation frequencies in TSSs and open-chromatin sites binned by mRNA abundance of target genes in matching tumour transcriptomes.Table S1D. Biological processes and molecular pathways with elevated mutation frequencies in TSSs. Table S1E. Localised mutation frequencies in CTCF sites grouped by conservation of CTCF binding in multiple cell lines. Table S1F. Localised mutation frequencies in CTCF sites grouped by motif presence and conservation of CTCF binding in multiple cell lines. Table S1G. List of hypermutated CTCF sites with constitutive binding and motifs (GRCh37). Table S1H. Interactions of genetic features (driver mutations, CNAs, genomic instability) and localised mutation frequencies. Table S1I. Genes in the identified CNA regions for which mRNA abundance increase is associated with copy number amplifications.