Phosphorylation of EGFR by SRC kinase

Besides autophosphorylation, EGFR can become tyrosine-phosphorylated by the action of the proto-oncogene tyrosine-protein kinase, c-src. This Src homology 2 (SH2) domain-containing protein is one of many such proteins which bind to phosphorylated sites on EGFR to affect signal transmission into the cell.

除自磷酸化之外，EGFR可被原癌基因酪氨酸蛋白激酶c-src的作用所酪氨酸磷酸化。此Src同源2（SH2）结构域包含蛋白为众多此类蛋白之一，这些蛋白能够结合至EGFR上的磷酸化位点，从而影响信号向细胞内部的传输。