Adipokine Signaling at the Crossroads of Metabolic Disorders and Implication in Tumor Progression

This review article “Adipokine Signaling at the Crossroads of Metabolic Disorders and Implication in Tumor Progression” contains the core review materials used to synthesize evidence on the role of adipokines in obesity-associated cancers. The underlying review examined how adipokines, especially leptin, adiponectin, resistin, visfatin, and chemerin, contribute to tumor progression and modulate cancer-related signaling pathways. It includes the literature search framework, study selection summary, adipokines investigated, associated signaling pathways, and major biological or clinical outcomes. The review findings were synthesized qualitatively because of heterogeneity in study designs and endpoints. Key pathways include JAK/STAT, PI3K/Akt/mTOR, MAPK/ERK, AMPK, NF-κB, and insulin/IGF-1 signaling.