Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane

Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane Descriptor: Beta-hexosaminidase 1, GLYCEROL, N-[(3S,4R,5R,6S)-4,5,6-trihydroxyazepan-3-yl]acetamide Authors: Vadlamani, G, Mark, B.L. Deposit date: 2013-09-18 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to beta-lactams. Chem.Commun.(Camb.), 49, 2013

洋葱伯克霍尔德菌（Burkholderia cenocepacia）糖苷水解酶家族3（family 3 glycoside hydrolase，NagZ）与(3S,4R,5R,6S)-3-乙酰胺基-4,5,6-三羟基氮杂环庚烷结合的晶体结构。描述项：β-己糖胺酶1（Beta-hexosaminidase 1）、甘油（GLYCEROL）、N-[(3S,4R,5R,6S)-4,5,6-三羟基氮杂环庚烷-3-基]乙酰胺。作者：Vadlamani G、Mark B.L.。存放日期：2013-09-18，发布日期：2013-10-30，最后修改日期：2023-09-20。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.8埃（Å））。引用文献：选择性三羟基氮杂环庚烷类NagZ抑制剂可增强铜绿假单胞菌（Pseudomonas aeruginosa）对β-内酰胺类抗生素的敏感性。《化学通讯（剑桥）》（Chem.Commun.(Camb.)），第49卷，2013年。