Association between GlycA and hsCRP levels and cardiovascular event in 4,759 participants (298 events) of the PREVEND study.

Hazard ratios were derived from Cox proportional hazards regression models.
Multivariable model 1: crude model + age, sex
Multivariable model 2: model 1 + BMI, alcohol intake, smoking status
Multivariable model 3: model 2 + type 2 diabetes mellitus, systolic blood pressure, lipid lowering drugs and anti-hypertensive medications
Multivariable model 4: model 3 + total cholesterol, HDL cholesterol, triglycerides.
Multivariable model 5: model 4 + eGFRcrea-cystatin C, UAE
Multivariable model 6: model 5 + hsCRP (for GlycA analyses) + GlycA (for hsCRP analyses).
Triglycerides, UAE and hsCRP were log transformed when used as a continuous variable in the analyses.
*Tests of trend across increasing quartiles were conducted by assigning the median for each quartile as its value and treating this as a continuous variable.
** 1 SD is 60.4 μmol/L for GlycA and 1.1 mg/L for hsCRP (hsCRP was natural log transformed). Abbreviations: BMI, body mass index; eGFRcrea-cysC, estimated glomerular filtration rate based on creatinine-cystatin C equation; HDL-cholesterol, high density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; UAE, urinary albumin excretion.
Association between GlycA and hsCRP levels and cardiovascular event in 4,759 participants (298 events) of the PREVEND study.