Quality assessment of diagnostic accuracy studies.

Summary of variables included in the QUADAS-2 tool assessing the quality of diagnostic accuracy studies. The criteria determined a study’s risk of bias or concern of applicability. When the domain-specific criteria were not met, the study had a high risk of bias or concern of applicability with respect to that domain. When the domain-specific criteria were all unclear, the risk of bias or concern of applicability was unclear.1 The currently available tests to detect typhoid fever are not sufficiently accurate; therefore, this question was problematic.2 “Unclear” = missing.Quality assessment of diagnostic accuracy studies.