Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex

Protein Data Bank Japan2024-10-30 更新2026-03-21 收录

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Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex Descriptor: 2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... Authors: Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. Deposit date: 2004-02-18 Release date: 2005-04-19 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005

人类DNA拓扑异构酶I（70 kDa）与吲哚并咔唑类化合物SA315F形成的复合物，以及与22碱基对DNA双链形成的共价复合物。结构描述符：2,10-二羟基-12-(β-D-吡喃葡萄糖基)-6,7,12,13-四氢吲哚并[2,3-a]吡咯并[3,4-c]咔唑-5,7-二酮，5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'，5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'，…… 作者：Staker, B.L.、Feese, M.D.、Cushman, M.、Pommier, Y.、Zembower, D.、Stewart, L.、Burgin, A.B. 存储日期：2004-02-18 发布日期：2005-04-19 最后修改日期：2024-10-30 实验方法：X射线衍射（分辨率3 Å）引用：《结合于人拓扑异构酶I-DNA共价复合物的三类抗癌剂结构》，J.Med.Chem., 48, 2005

创建时间：

2004-02-18