URE3 motif in promoters of genes modulated by a dominant positive URE3-BP

Identity (Pathema Locus number) and gene annotation of significantly modulated genes are shown in conjunction with the observed change between induced EF(2)mutURE3-BP and STOP- EF(2)mutURE3-BP strains. The distance between the URE3 motif and the presumed initiating ATG codon is shown as is the position of other potential URE3 motifs, the promoter consensus URE3 motif, and orientation.1If the motif is present in the promoter in a 5�� to 3�� direction this is indicated by (+) and on the reverse strand by (?).2These transcripts were decreased in recent clinical isolates [4]3Was modestly induced by tetracyclin at below threshold values4These transcripts were increased in recent clinical isolates [4]5This probe set recognizes a gene shown to be up regulated in HM-1:IMSS compared to a Rahman strain [3]6A signal peptide was found in either the 5�� extended open reading frame or 3�� of initiating ATG, the position of URE3 motif is shown from the newly designated initiating ATG7Annotation on the basis of homology to known sulfotransferases8This transcript was also significantly increased in the EF(2)mutURE3-BPuninduced ameba compared to the uninduced control.9This gene was described by Nixon et al and has been shown to be up regulated in HM-1:IMSS compared to a Rahman strain [3],[45]