GENERALIZATION.

Evidence for quantitative associations (BMI or standard deviation score of BMI (BMI-SDS)) assessed cross-sectionally for 5 loci (10 SNPs) under an additive genetic model. Effect sizes as point estimators and 95% confidence intervals (95% CI), p-values (two-sided) and combined effect estimators and p-values are presented for the adults with abbreviations for the samples: KORA, SHIPc, EPIC-Potsdam, Heinz-Nixdorf Recall Study; all samples are described in detail in Text S1. aposition and stranding according to dbSNP BUILD 129; Map to Genome Build 36.3; b(obesity) effect risk alleles as derived from the paediatric extreme obesity GWAS meta-analysis; cresults for SHIP are based on in silico GWAS data–proxy markers (FTO: rs8050136 for rs9935401, rs1421085 for rs1558902; MC4R: rs476828 for rs17700144); one marker for each region was regarded as sufficient if the others were not available; dBMI-SDS is a normalized version of BMI expressed as standard deviation score that includes information on age and gender; the results were similar if age and gender were included as covariates; eby inverse normal method (function metagen in the package meta of R) with weights proportional to the sample size (fixed effects model).