DECREASED VEGF EXPRESSION AS AN IMMUNOHISTOCHEMICAL MARKER OF IMPAIRED PLACENTAL ANGIOGENESIS IN SEVERE MATERNAL ANEMIA COMPLICATED BY PLACENTAL ABRUPTION

Placental abruption is a severe obstetric complication associated with acute disruption of uteroplacental circulation and adverse maternal and perinatal outcomes. Current concepts suggest that placental abruption may represent the final manifestation of a prolonged pathological process involving placental ischemia, endothelial dysfunction, impaired remodeling of spiral arteries, and structural abnormalities of the villous vascular network.