Data and code for mechanistic scenario modeling of indomethacin release from freeze-dried pullulan/HM-HPMC matrices

This deposit contains the data and code supporting mechanistic scenario modeling of indomethacin release from freeze-dried pullulan/HM-HPMC matrices. It includes 21 computational CSV output files, an experimental-dimensions provenance CSV, Python scripts, model inputs, software requirements, computational figures, SHA-256 checksums and the original experimental workbook. Six computational studies examine hydration-dependent diffusion, dissolution-limited availability, receiving-fluid conditions, sensitivity and uncertainty, loading optimization, and virtual experimental design. Recorded F2 dry thickness provides the reference geometry. Transport parameters are scenario assumptions; no experimental release measurements were used for calibration or validation. Simulated transfer fractions are normalized to specified initial retained drug mass. The README provides execution instructions and explains the limitations of the experimental records and computational predictions.