Haplotype designations 1A-16A are by Sahagun-Ruiz et al.[2]. B, C and D show haplotypes in which the SNP does not change the amino acid compared to A [4]. The table includes the FPR1 SNPs in the follo
The alignments and data are the same as those used in Table 4. The number of deleterious SNPs is the difference between the total and neutral number of SNPs. The number of neutral nonsynonymous SNPs i
*Meta-analysis for pooled cohorts (Spanish and US) was performed using the Mantel-Haenszel test implemented in SAS 9.0. **Refers to the individual results obtained for the whole US replication cohort.
The analysis of large genomic data is hampered by issues such as a small number of observations and a large number of predictive variables (commonly known as “large P small N”), high dimensionality or
