官方服务：
资源简介：
Public description
应用场景：
创建时间：
2019-09-23
相关数据集
Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy [miR146aKO_LSK_WGBS]
Aging is associated with significant changes in the hematopoietic system, including increased inflammation, impaired hematopoietic stem cell (HSC) function, and increased incidence of myeloid malignan
NIAID Data Ecosystem20
Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction. Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
Abstract: Protein homeostasis (proteostasis) is critical for cell function, and its decline is proposed as a hallmark of aging. Somatic stem cells (SCs) have a unique ability to maintain their proteos
NIAID Data Ecosystem20
Organelle dysfunction upon asrij depletion causes aging-like changes in mouse hematopoietic stem cells
Asrij deletion in mice causes loss of HSC quiescence, myeloid skewing, reduced p53 and increased DNA damage, features attributed to aged hematopoietic stem cells (HSCs). To identify the pathways and p
NIAID Data Ecosystem10
Cholesterol metabolism-related gene expression in ACP, PCP and PA; htNSC senescence process due to ACP cystic fluid. Cholesterol metabolism-related gene expression in ACP, PCP and PA; htNSC senescence process due to ACP cystic fluid
This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series
NIAID Data Ecosystem20
Aging Decline of LEPR+ HSCs
Leptin receptor (LEPR) identifies a subpopulation of hematopoietic stem cells (HSCs) with high repopulating potential. In this study, we demonstrated that LEPR-expressing HSCs while exhibiting signifi
NIAID Data Ecosystem20
