Expression data of lung tissues of rats exposed to chronic hypoxia

Under hypoxic exposure in rats, activation of VEGF/Notch pathway may lead to pulmonary angiogenesis, and the expression of related proteins may be associated with down-regulation of miRNAs. We used microarrays to screen out miRNAs related to VEGF/Notch pathway in hypoxic exposure, and in this process, we found genes with a downregulation trend with prolonged exposure time. Lung tissues of male SD rats were selected for RNA extraction and hybridization on Affymetrix microarrays. In order to further screen out hypoxia genes related to VEGF/Notch pathway and explore their tendency and downregulation with the increase of hypoxia exposure time. To this end, rats were divided into the normoxic control group (C)h and the rat exposure time of 24 hours (H_24), 48 hours (H_48) and 72 hours (H_72) groups.