Additional File 2:

Table S1. Description of all the covariates used in the study. Table S2. Spearman correlations of all the covariates with four α-diversity metrics. Table S3. Results of multivariable ANOVAs with α-diversity metrics. Table S4. PERMANOVA results for all of the covariates with three β-diversity indexes. Table S5. Results of multivariable PERMANOVAs with β-diversity indexes. Table S6. Explained cumulative variance of Bray-Curtis dissimilarity metric by all non-genetic covariates (dietary and 110 tested in this study). Table S7. List of taxa tested for association with genetic variants. Table S8. MaAsLin test results between 110 non-genetic variables and 475 taxa. Table S9. List of identified covariates that were used for each phenotype in addition to the first two principal components of the genotyping matrix. Table S10. List of SNPs with association p-value < 10-6 with α-diversity metrics. Table S11. List of SNPs with association p-value < 10-6 with β-diversity indexes. Table S12. Replication of the SNPs previously reported to be associated with β-diversity. Table S13. Nominal associations of SNPs with relative abundances of taxa. Table S14. Nominal associations of SNPs with dichotomized taxa in the MI cohort. Table S15. Replication of the SNPs previously reported to be associated with individual taxa. Table S16. Mean relative abundance of major phyla in MI and other studies. (XLSX 1442 kb)