Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA

Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA Descriptor: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], N-((3R,5S)-1-(benzofuran-3-carbonyl)-5-(ethylcarbamoyl)pyrrolidin-3-yl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Encinas, L, OKeefe, H, Neu, M, Convery, M.A, McDowell, W, Mendoza-Losana, A, Pages, L.B, Castro-Pichel, J, Evindar, G. Deposit date: 2014-01-28 Release date: 2014-02-12 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium Tuberculosis Inha. J.Med.Chem., 57, 2014

本数据集以编码文库技术（Encoded Library Technology）作为一类强效、选择性结核分枝杆菌（Mycobacterium tuberculosis）InhA直接杀菌抑制剂的发现与先导化合物优化的命中化合物来源。
描述项：烯酰-[酰基载体蛋白]还原酶[NADH]、N-((3R,5S)-1-(苯并呋喃-3-羰基)-5-(乙基氨基甲酰基)吡咯烷-3-基)-3-乙基-1-甲基-1H-吡唑-5-甲酰胺、烟酰胺腺嘌呤二核苷酸（NICOTINAMIDE-ADENINE-DINUCLEOTIDE）
作者：Encinas L、O'Keefe H、Neu M、Convery M.A.、McDowell W、Mendoza-Losana A、Pages L.B.、Castro-Pichel J、Evindar G
提交日期：2014年1月28日
发布日期：2014年2月12日
最后修改日期：2023年12月20日
检测方法：X射线衍射（分辨率2.4 Å）
引用文献：Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium Tuberculosis Inha. J.Med.Chem., 57, 2014