WRN loss accelerates abnormal adipocyte metabolism in Werner Syndrome

Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) and in vivo (zebrafish). Moreover, WRN depletion causes a transient upregulation of late-stage of adipocyte-specific genes at an early stage. Overall design: RNA-sequencing (RNA-seq) for WRN in human mesenchymal stem cells (hMSCs).