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Intestinal taurine acts as a novel immunometabolic modulator of IBD by degrading redundant mitochondrial RNA (PRJCA031238)

NIAID Data Ecosystem2026-05-10 收录

炎症性肠病(IBD)

免疫代谢

数据链接：

https://www.ncbi.nlm.nih.gov/sra/DRP016285 数据链接链接失效反馈

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Intestinal taurine acts as a novel immunometabolic modulator of IBD by degrading redundant mitochondrial RNA

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创建时间：

2025-12-11

细胞信号传导

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Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWAT).

NIAID Data Ecosystem80

Pro-survival Lipid Sphingosine-1-Phosphate Metabolically Reprograms T cell to Limit its Anti-Tumor Activity

免疫代谢

T细胞功能调控

Sphingosine 1-phosphate (S1P), a pro-tumor survival bioactive lysophospholipid, generated by sphingosine kinase 1 (SphK1), regulates lymphocyte egress into circulation via transducing S1P receptor 1 (

NIAID Data Ecosystem50

Expression of HPGD in regulatory T cells prevents adipose tissue inflammation and metabolic dysfunction (data set 2)

免疫代谢

脂肪组织稳态与代谢疾病

Regulatory T cells (Treg cells) are important for the prevention of autoimmunity and lately, their role in maintaining tissue homeostasis has been demonstrated. They exert their function via different

NIAID Data Ecosystem30

Additional file 8: of Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10

转录组学分析

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GSEA core enrichment - Oxphos - IL-10 immunodepleted vs low LPS plasma. (XLS 61 kb)

NIAID Data Ecosystem70

D- 2-hydroxyglutarate is an immunometabolite that accumulates in macrophages after TLR activation and inhibits inflammatory responses

免疫代谢

巨噬细胞炎症抑制

Macrophages undergo extensive metabolic rewiring upon activation and this serves many roles beyond the production of energy and anabolic building blocks. So-called immunometabolites that accumulate up

NIAID Data Ecosystem30

Intestinal taurine acts as a novel immunometabolic modulator of IBD by degrading redundant mitochondrial RNA (PRJCA031238)

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