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Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution

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Protein Data Bank Japan2025-03-19 更新2026-03-21 收录
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Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... Authors: Khabibullina, N.F, Tereshchenkov, A.G, Komarova, E.S, Syroegin, E.A, Shiriaev, D.I, Paleskava, A, Kartsev, V.G, Bogdanov, A.A, Konevega, A.L, Dontsova, O.A, Sergiev, P.V, Osterman, I.A, Polikanov, Y.S. Deposit date: 2019-03-28 Release date: 2019-04-17 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides. Antimicrob.Agents Chemother., 63, 2019

分辨率为2.80Å的嗜热栖热菌(Thermus thermophilus)70S核糖体与地红霉素结合,并结合mRNA以及A、P、E位点tRNA的晶体结构。 描述符:16S核糖体RNA(16S Ribosomal RNA)、23S核糖体RNA(23S Ribosomal RNA)、30S核糖体蛋白S10(30S ribosomal protein S10)…… 作者:Khabibullina, N.F、Tereshchenkov, A.G、Komarova, E.S、Syroegin, E.A、Shiriaev, D.I、Paleskava, A、Kartsev, V.G、Bogdanov, A.A、Konevega, A.L、Dontsova, O.A、Sergiev, P.V、Osterman, I.A、Polikanov, Y.S 提交日期:2019-03-28 发布日期:2019-04-17 最后修改日期:2025-03-19 实验方法:X射线衍射(X-RAY DIFFRACTION),分辨率2.8 Å 引用文献:《结合细菌核糖体的地红霉素结构提示大环内酯类药物理性改良新路径》,《抗微生物剂与化疗》,63卷,2019年
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2019-03-28
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