Dose-response relationships for individual drugs included in the analyses.

The RR values in this table differ from those in Table 1 because only a sub-set of all available studies reported dose-response relationships. “Low” and “high” daily doses of ibuprofen, naproxen, and diclofenac were defined in the individual studies as follows. Ibuprofen low dose/high dose: eight studies, ≤1,200 mg/>1,200 mg; one study, ≤1,600 mg/>1,600 mg; two studies, 500 mg; four studies, ≤750 mg/>750 mg; four studies, ≤1,000 mg/≥1,000 mg. Diclofenac low dose/high dose: six studies, ≤100 mg/>100 mg; two, studies