Comprehensive molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells

We aimed to elucidate the molecular features and identify causative factors for PCOS through an integrated, transcriptomic analysis of oocytes and cumulus granulosa cells (GCs) from the same patients with PCOS We obtained matched oocytes and GCs from three PCOS patients and compared them with age-matched, women without PCOS, and performed RNA sequencing analysis to explore the transcriptional characteristics of their oocytes and GCs