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Mutated SOD1 immunoprecipitation samples in the nucleus and cytoplasm from the ALS model mouse-derived cell line DF7.
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2024-01-27
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ALS implicated protein TDP-43 sustains levels of STMN2 a mediator of motor neuron growth and repair. ALS implicated protein TDP-43 sustains levels of STMN2 a mediator of motor neuron growth and repair
The discovery that TDP-43 mutations cause familial ALS and that many patients display pathological TDP-43 mislocalization has nominated altered RNA metabolism as a potential disease mechanism. Despite
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Abnormal Changes in NKT Cells, the IGF-1 Axis, and Liver Pathology in an Animal Model of ALS
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing fatal neurodegenerative disorder characterized by the selective death of motor neurons (MN) in the spinal cord, and is associated with loca
Figshare2016-01-18 更新10
An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS [scRNA-Seq]
To uncover molecular determinants of motor neuron degeneration and selective vulnerability in amyotrophic lateral sclerosis (ALS), we performed longitudinal single-nucleus RNA sequencing, paired singl
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Fig. 3d | TDP-43 localization and phosphorylation in ALS motor neurons
This item is part of the Figshare Project: Early mitochondrial dysfunction revealed across FUS- and TARDBP-ALS at single cell resolution From Data Availability Statement for the paper in Nature Comm
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Effects of overexpression of GFP-TDP-43, GFP-TDP-43(86-414) or GFP in human H4 cells, in the presence or absence of the EIF2B activator DNL343.
Neuronal TDP-43 aggregates are a hallmark ALS pathology. The integrated stress response (ISR) occurs downstream of TDP-43 pathology and may exacerbate TDP-43 aggregation and neurodegeneration. Here we
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