A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer. Zheng et al.
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In a study exploring the intricate relationship between PDAC matrix stiffness and the Warburg effect, Zheng et al. reveal CLIC1 as a critical mediator. Matrix stiffness increases CLIC1 levels through the Wnt/β-catenin/TCF4 pathway, correlating with adverse outcomes and tumor progression. Reducing matrix stiffness may offer therapeutic benefits by targeting CLIC1.
This data is the original immunoblotting data of the above study.
