A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer. Zheng et al.

In a study exploring the intricate relationship between PDAC matrix stiffness and the Warburg effect, Zheng et al. reveal CLIC1 as a critical mediator. Matrix stiffness increases CLIC1 levels through the Wnt/β-catenin/TCF4 pathway, correlating with adverse outcomes and tumor progression. Reducing matrix stiffness may offer therapeutic benefits by targeting CLIC1. This data is the original immunoblotting data of the above study.在一项探究胰腺导管腺癌（Pancreatic Ductal Adenocarcinoma, PDAC）基质刚度与瓦伯格效应（Warburg effect）之间复杂关联的研究中，郑等揭示氯离子细胞内通道1（Chloride Intracellular Channel 1, CLIC1）为关键介导因子。基质刚度可通过Wnt/β-连环蛋白/TCF4通路上调CLIC1的表达水平，且与不良预后及肿瘤进展密切相关。降低基质刚度或可通过靶向CLIC1实现治疗获益。 本数据集即为上述研究的原始免疫印迹（immunoblotting）数据。