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VHL/HIF2a axis alters transcriptomic profiles in ccRCC

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NIAID Data Ecosystem2026-03-12 收录
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VHL loss is the most common genetic alteration event in ccRCC. VHL loss stabilizes hypoxia-inducible factor-2 alpha (HIF2a). We compared the changes in transcriptomics profiles after VHL restoration or HIF2a siRNA knockdown in 786-O cells. RNA-seq profiles of ccRCC cell line 786-O with and without wild-type VHL restoration, with non-targeting control or pooled siRNA against HIF2a

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2021-07-25
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