SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

SARS-CoV-2 booster immunizations in humans induce robust germinal centre B cell responses and can generate de novo B cell responses targeting variant-specific epitopes. Examination of 39 single-cell RNA-seq samples from PBMCs and from fine need aspirations of lymph nodes taken at multiple time points post-vaccination across multiple participants.