The impact of the anticoagulant type in blood collection tubes on circulating plasma miRNA profiles revealed by small RNA sequencing. The impact of the anticoagulant type in blood collection tubes on circulating plasma miRNA profiles revealed by small RNA sequencing

Pre-analytic factors have a significant influence on circulating miRNA profiling. The aim of this study was the comprehensive NGS-based assessment of the impact of anticoagulant type in blood collection tubes on circulating plasma miRNA profiles. Overall design: Comparative miRNA profiling analysis of miRNA-Seq data for plasma extracellular circulating miRNA obtained from blood collected with different anticoagulants (ACD-B, Sodium citrate, CTAD and K2-EDTA) from 10 healthy participants.