Replication Data for: The BCG-Corona randomized placebo-controlled trial in Dutch healthcare workers

This record includes meta-data from the BCG-Corona trial, a double-blind, placebo-controlled randomized trial comparing BCG to placebo vaccination to prevent unplanned absenteeism and COVID-19-related endpoints in healthcare workers in nine Dutch hospitals. Healthcare workers were randomized to BCG or placebo vaccination (1:1) in March and April 2020 and followed for one year. They reported daily symptoms, SARS-CoV-2 test results, and healthcare seeking behavior via a smartphone application, and donated blood for SARS-CoV-2 serology at two timepoints. BCG vaccination did not reduce unplanned absenteeism, SARS-CoV-2 infections, or SARS-CoV-2 infection duration or severity. Nasopharyngeal rest materials after SARS-CoV-2 testing were stored in two of the nine hospitals and used for 16S microbiome sequencing and viral panel testing. Those results are pending.