Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.
收藏PubMed Central1996-06-25 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC39073/
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资源简介：
Gadolinium(III) texaphyrin (Gd-tex2+) is representative of a new class of radiation sensitizers detectable by magnetic resonance imaging (MRI). This porphyrin-like complex has a high electron affinity [E1/2 (red.) approximately = -0.08 V versus normal hydrogen electrode] and forms a long-lived pi-radical cation upon exposure to hydrated electrons, reducing ketyl radicals, or superoxide ions. Consistent with these chemical findings, Gd-tex2+ was found to be an efficient radiation sensitizer in studies carried out with HT29 cells in in vitro as well as in in vivo single and multifraction irradiation studies with a murine mammary carcinoma model. Selective localization of Gd-tex2+ in tumors was confirmed by MRI scanning. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-06-25
