The relationship between 25 Plasmepsin II inhibitor compounds activities and eleven structural and chemical properties was explored and several models proposed.
Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has y
ITDR MS-CETSA was conducted on MMV006656-treated live parasites and lysate of P. falciparum trophozoites in order to identify potential drug protein targets.
