Efficient Preparation of 2,4-Diaminopyrimidine Nucleosides: Total Synthesis of Lysidine and Agmatidine
收藏Figshare2016-02-20 更新2026-04-29 收录
下载链接：
https://figshare.com/articles/dataset/Efficient_Preparation_of_2_4_Diaminopyrimidine_Nucleosides_Total_Synthesis_of_Lysidine_and_Agmatidine/2495581
下载链接
链接失效反馈官方服务：
资源简介：
An efficient route for the synthesis of 2,4-diaminopyrimidine ribosides from cytidine is described consisting of six steps with overall yields >50% and only one chromatographic step. The key amine addition step utilizes LiCl and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to ensure clean conversion to a single tautomeric product. This route has been used to prepare the modified tRNA nucleosides lysidine and agmatidine in quantities suitable for structural characterization.
创建时间：
2016-02-20
