RSDB

In this work, we designed and constructed a rare skin disease database (RSDB) as a disease-centered information depository to facilitate repurposing drug candidates for rare skin diseases. We collected and integrated associated genes, chemicals, and phenotypes into a network connected by pairwise relationships between different components for rare skin diseases. The RSDB covers 891 rare skin diseases defined by the Orphanet and GARD databases.本研究设计并构建了罕见皮肤病数据库（Rare Skin Disease Database, RSDB），作为以疾病为中心的信息存储库，旨在助力罕见皮肤病候选药物的重定位研究。我们收集并整合了罕见皮肤病相关的基因、化学物质与表型，构建出一张由不同组分间两两关联关系连接而成的关联网络。该数据库涵盖了由孤儿病数据库（Orphanet）与基因与罕见病信息中心（GARD）所定义的891种罕见皮肤病。

搜集汇总

背景与挑战

背景概述

RSDB是一个罕见皮肤疾病数据库，旨在通过整合基因、化学物质和表型信息来促进药物再利用。该数据库覆盖了891种罕见皮肤疾病，构建了这些元素之间的关联网络，为用户提供疾病相关的综合数据。