Chronic sleep deprivation alters intestinal microbiota resulting in metabolic disorders Raw sequence reads. intestinal microbiota

The circadian clock controls diurnal and nocturnal variations in physiological processes. The role of circadian clock is tightly linked to the genetic and molecular makeup of an individual. Studies have found that the quantity and composition of gut microbes change over time and can be directly affected by the biological clock. Moreover, disorders of circadian clock affect gut microbes, which may lead to some intestinal diseases; even metabolic syndromes. We used a rat model of chronic sleep deprivation and monitored the changes of intestinal microbiota diversity of chronic sleep deprivation