Estimating escape rates using parent-child variants removes the bias associated with concurrent escapes.

We use the same simulations as described in Table 1, but estimate escape rates using Eq (2). As in Table 1, we show relative error in estimated escape rates. Note that in this analysis we track escape variant haplotypes using linkage information available from simulations. Notations are identical to those shown in Table 1. Of note, negative bias less than negative one implies that the method estimates negative escape rate (decline in frequency of the escape variant).