HAND2 Targets Define a Network of Transcriptional Regulators that Compartmentalize the Early Limb Bud Mesenchyme
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Highlights • ChIP-seq identifies the CRMs bound by endogenous HAND2 in embryos and limb buds • HAND2 controls key transcriptional regulators acting upstream of SHH in limb buds • These transcriptional circuits define proximal, anterior, and posterior identities • HAND2 establishes anterior and posterior compartments by regulating <em>Gli3</em> and <em>Tbx3</em>
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2021-01-11
